P407 Predictive factors for the efficacy of leukocytapheresis in ulcerative colitis

Abstract

And the dose of prednisolone (PSL) at baseline was also significantly higher in the refractory group than the response group (p = 0.005). Multiple logistic regression analysis showed that high daily PSL dose (p = 0.032, 95%CI 1.014 1.363) at baseline and high CAI score at 7 days after achieving high trough level (p = 0.047, 95%CI 1.007 3.065) were significant predictive factors for the refractory to TA therapy. Conclusions: Higher activity and higher daily PSL dose at baseline, poor response at 7 days after achieving high trough level were predictive factors for refractory to TA therapy. These refractory patients should be changed to alternative treatment including surgery without missing the appropriate timing.