Abstract
Methods 9 children (1.1-4.7 yr) with documented IgE-mediated cow milk (CM) allergy participated. DBPCFC were performed over a 3-d period in hospital using procedures described by Sampson et al (J Pediatr;118:520). A DBPCFC was performed on each of the first 2 d. Day 3, an open challenge of EF was done. Challenges were 100 mL of placebo (P) formula (Nutramigen liquid, Mead Johnson Nutritionals, Evansville, IN) or EF (Nutramigen containing 8 g freeze-dried Similac Alimentum, Abbott Nutrition (AN), Columbus, OH). Flavoring (chocolate or strawberry syrup) was optional and, if chosen, used in all challenges.
Highlights
Recommendations/regulations dictate the testing of hypoallergenic formula in allergic patients prior to marketing
At entry 6 subjects received a challenge to cow milk (CM) with positive results
The amount of CM protein eliciting a response ranged from 0.063-1.54 g. 3 subjects had a repeat reaction to CM due to accidental exposure just prior to entry and were not re-challenged. 8 subjects successfully completed the DBPCFC and open feeding of EF; 1 with a history of anaphylaxis to CM reacted to P and EF. 3 mo later, the subject returned for repeated DBPCFC because the syrup was suspected
Summary
Recommendations/regulations dictate the testing of hypoallergenic formula in allergic patients prior to marketing. P40 - Double-blind, placebo-controlled, food challenges (DBPCFC) of a strong tasting food: lessons learned From 3rd Pediatric Allergy and Asthma Meeting (PAAM) Athens, Greece. Background Recommendations/regulations dictate the testing of hypoallergenic formula in allergic patients prior to marketing.
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