P4 Gastric cancer and CNS involvement registry

Abstract

memorial cancer hospital from July 2006 to june 2012 were reviewed retrospectively. Patients with gastric outlet obstruction were treated by upfront surgery followed by adjuvant chemotherapy while rest were managed with perioperative chemotherapy as per the MAGIC trial protocol [3]. D1 plus nodal dissection was performed. Primary end point was overall survival after a minimum follow up of 15 months. For categorical data frequencies were calculated and means were measured for continuous variables. Chi square test was used to compare categorical data and Kaplan Meir survival analysis was performed to estimate 5-year survival outcome using SPSS. Results: Majority of the patients were male with median age of 51 years. Perioperative chemotherapy was offered to 75 patients while upfront surgery was performed in 23 patients. In perioperative chemotherapy group 51 patients and 22 in the upfront surgery group ended up having curative resection. The 5-year survival (n = 98) was found to be of 37%. The 5-year survival of patients in perioperative chemotherapy group (n = 75) was 44% while those who had a curative resection (n = 73) had a survival of 46%. Statistically significant difference was present for the actual number of observed mortalities for patients with poorly differentiated carcinoma (p = 0.005) and extranodal extension (p = 0.002). Conclusion: Gastric adenocarcinoma is an aggressive disease. Perioperative chemotherapy works well in Pakistani population as the results at our institution are comparable with international data