P4‐423: RGS‐14(414) gene delivery into brain area V2 induces both the recovery and prevention of recognition memory in ageing and Alzheimer's disease

Abstract

neurogenesis and maturation of newly generated neurons in the brain of subjects with AD and delay or prevent the progression of the disease is stimulation of endogenous neurotrophic factors. Neurotrophic factors a family of structurally related, secreted proteins, consisting of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), ciliary neurotrophic factor (CNTF), NT-3, and NT4/5, are small proteins that provide trophic events in neuronal cells. These secreted neurotrophic factors act by binding to the specific cell surface receptors that signal the neuron to survive. Methods: Neurotrophic factors are important in the developing and mature nervous system. They influence cell proliferation, survival, differentiation, migration, axon and dendritic growth and synaptic plasticity. They play critical roles in complex behaviors including anxiety, depression and learning. They can be given exogenously as pure proteins or through gene therapy to prevent nerve cell death caused by various insults including nerve injury, brain trauma, and exposure to toxins. Results: The high potency of neurotrophic factors, as shown by many experimental studies, makes them a rational candidate therapeutic agent in neurodegenerative disease. Because the administration of exogenous neurotrophic factors is time consuming and expensive for the most of patients and also it needs to gene delivery, intense care considerations and probably it’s side effects, therefore it seems that the manipulation of endogenous neurotrophic factors is suitable treatment for AD.Conclusions: It is concluded that the manipulation and stimulation of endogenous neurotrophic factors is a promising therapeutic strategy in Alzheimer’s disease.