P4‐324: Aβ inhibits specific kinesin motors involved in both mitosis and neuronal function; potential implications for neurogenesis and neuroplasticity in Alzheimer's disease and Down syndrome

Abstract

phosphorylation at sites Ser199/202, Thr231/Ser235 and Ser396/404 but not at sites Thr212/Ser214. Since it was reported that As could affect synaptic NMDA responses, we analyzed the effect of As on tau phosphorylation. In this regard, we found that As increases tau phoshorylation at sites Thr231/ Ser235 and Ser396/404 but not at sites Ser199/202 and Thr212/Ser214 after five days incubation in hippocampal slice cultures.Conclusions:Our results suggest a common pathway between As and NMDA receptor activation. Furthermore our data showed that tau phosphorylation caused by NMDA receptor activation is occluded by prior incubation with As.