Abstract
Cholera is characterised by massive secretory diarrhoea. This is due to an exotoxin, Cholera toxin (CT), which acts via the mucosal epithelium to produce large increases in the activity of enteric secretomotor neurons. We have shown that this increased activity is due, in part, to increased excitability of secretomotor neurons [1]. In work to be presented at this meeting, we have also shown that luminal exposure of CT in jejunum also increases the excitability of intrinsic sensory neurons. However, while the effects of CT on secretion are well established, any effects on motility are less well understood.
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