Abstract
progranulin-positive capillary densities (P<0.005). In temporal cortex, progranulin-positive capillary densities correlated with DP, but not NP or NFT (P<0.01). Conclusions: This study is the first to link progranulin to microvascular alterations in AD. These microvascular alterations were most closely associated with the earliest pathological features of Alzheimer’s in each discrete area (neurofibrillary tanlges in hippocampus and diffuse amyloid plaques in neocortex). These findings suggest that aberrant wound-healing and angiogenesis may play a role in the early pathogenesis of AD and have implications for the development of new therapeutic strategies for AD.
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