Abstract
1. The drug-metabolizing activities (aminopyrine N-demethylase and p-nitroanisole O-demethylase activities) have been measured at monthly intervals throughout the year in liver microsomes of male and female Japanese bullfrogs, Rana catesbeiana.2. The aminopyrine n-demethylase activity based on cytochrome P-450 of both sexes was significantly higher in May–July (spring-summer) than in August–October (summer-autumn).3. On the contrary, the p-nitroanisole O-demethylase activity based on cytochrome P-450 of males was significantly higher in July–October (summer-autumn) than in May–June (spring). However, there was no seasonal changes in the O- demethylase activity in females.4. There were significant differences between males and females in the n-demethylase activity in August–October and in the O -demethylase activity in May–June (or July–October).
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