P397. Genomic Deletions and Duplications Show Mirror Effects on Cognitive Ability According to Spatial Patterns of Gene Expression in the Human Brain

Abstract

Genomic deletions or duplications, which increase risk for neurodevelopmental-psychiatric-disorders, can contain several genes and decrease or increase gene-expression respectively. Studies have estimated that 50% of coding genes show measurable effects on cognitive-ability when deleted or duplicated. Genes with large effect-sizes show enrichment in molecular/cellular functions. However, these functions only apply to small groups of genes. We hypothesize that spatial patterns of gene-expression reflect macroscale brain functions and will shed light on the effects of large groups of genes.