Abstract
Abstract Background Postoperative anastomotic fistula is one of the most frequent and potentially life-threatening complications following gastrointestinal resections in patients with Crohn’s disease. The purpose of this study was to report the results of using infliximab to treat postoperative anastomotic fistula in patients with Crohn’s disease. Methods A prospective parallel study of fibrin glue combined with infliximab vs. fibrin glue treatment was conducted. Demographic and clinical characteristics and outcomes were compared between the groups. Results Thirty-five patients with postoperative anastomotic fistula were evaluated; 14 received fibrin glue combined with infliximab treatment and 21 received fibrin glue treatment. No significant differences in demographic or clinical characteristics were found between the two groups (all p > 0.05). There were two recurrences in the fibrin glue group, and no recurrences in the fibrin glue combined with infliximab group(p = 0.506). No complications occurred in either group. Conclusion Infliximab strategy with combining fibrin glue is a simple and effective treatment alternative in the management of postoperative anastomotic fistula in Crohn’s disease.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
