Abstract

Abstract Background Brugada syndrome is a genetically determined disease that predisposes to the risk of malignant ventricular arrhythmias and can cause sudden death in young adults with structurally healthy hearts. Currently the main treatment consists in the implantation of the defibrillator (ICD) but new therapeutic profiles emerge from the literature. Objective To redefine the recommendations on early diagnosis and treatment of brs (Brugada syndrome). Provide an overview of the orientation and new clinical pathways emerging from scientific literature Materials and Methods A critical review of the literature was conducted, on the major MEDLINE data bases through PUB MED, CHINAL, COCHRANE LIBRARY and Google schoolar to narrow the search we used mesh terms from the thesaurus library. RCT, meta–analysis, systematic and scoping reviews in English published in the last 5 years for a total of 31 articles Results we estimated an average value of brs in young subjects (between 35 and 65 years) of about 9300 cases per year (∼ 17% of the total): the causes of the phenomenon vary greatly: in older subjects the pathology is more frequently associated with arrhythmic disorders. The review identified ICD implantation as a Class 1 indication in individuals who survived cardiac arrest and had ventricular tachycardia with or without syncope. The radiofrequency ablation technique, on the other hand, involves a preliminary electrophysiological study to identify the epicardial arrhythmogenic substrate. Therefore it seems that epicardial ablation will currently serve as an adjuvant rather than a real alternative to the ICD implant Conclusions Currently, no drug therapy can prevent sudden death in patients with brs some drugs are very effective in reducing symptoms or treating arrhythmias induced by ICD, therefore defibrillator implantation associated with different levels of therapeutic education is recommended, Early diagnosis with radiofrequency ablation technique that actually produces a realignment of the ST tract but in fact does not reduce arrhythmogenic events from the results there are no solving techniques other than the ICD impaction. Therapeutic education is an absolutely effective tool to improve the management of ICD–carrying patients with brs.

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