P368 IS HBA1C CORRELATED TO RESTING ENERGY EXPENDITURE IN TYPE 2 DIABETIC PATIENTS? A PILOT STUDY

Abstract

leptin, ultrasensitive CRP (usCRP), IL1-beta, IL6, TNFalpha and homocystein prior and after treatment. Results: In the whole group we founded a decrease in ALT levels in 43 patients (58.10%) reaching normal levels only in 22 (29.72%). There was a decrease in HOMA-IR, PCRus, IL-6, homocystein and ferritin, reaching statistical significance only in leptin levels (1.99±2.21 vs 1.05±1.12; p = 0.023) observed in 53 patients (71.62%). Analyzing pre-treatment ALT elevated levels patients subgroup we founded a significant decrease in HOMA-IR in those that reach normal levels in contrast with those with persistent elevated ALT levels (4.23±2.83, 2.36±1.19, 4.07±3.72; p = 0.02), accompanied of a significant decrease TNFalpha (6.80±1.61, 4.67±1.28, 6.82±2.66; p = 0.007). We had similar results regarding to TNF-alpha in patients with elevated pre-treatment HOMA-IR that reach normality (6.80±1.61, 4.06±1.5, 7.56±0.80; p = 0.04). In spite of a decrease in other proinflammatory factors level after 6mo of treatment in this subgroup, they not reach statistical significance. We not observed significant decrease in patients with normal pre-treatment ALT or HOMA-IR <3.9. Conclusion: After 6 mo of integral treatment of patients with NAFLD, persisted a proinflammatory state in spite of a decrease in insulin-resistance (HOMA-IR) and factors related. This decrease reached statistical significance in patients with pre-treatment elevated ALT levels that normalised them, reinforcing a role HOMA-IR and TNFalfa in such elevated levels.