P-365 - The relationship between working memory and clinical and functional outcomes in first psychotic episodes

Abstract

Introduction The relationship between neurocognitive course and clinical and functional outcomes in psychosis is not well known, especially in the long term. Objectives The aim of the study was to examine the clinical and neuropsychological course of first psychotic episode patients at 5 follow-up years and analyze the relationship between cognitive performance and clinical and functional outcome. Methods The five follow-up years was conducted with 26 (58%) of patients recruited who met inclusion criteria and provided informed consent to participate. Psychotic symptoms were measured by Positive and Negative Symptom Scale, manic and depressive symptoms by Young Mania Rating Scale and Hamilton Depression Rating Scale respectively, and psychosocial functioning by Functioning Assessment Short Test. We used repeated measures analysis, Kruskal Wallis and linear regression models (SPSS 18.0). Results Patients experienced symptomatic improvement in the follow up except in negative psychotic symptoms (F = .149; p Conclusions There was improvement in most cognitive domains and a symptomatic and functional recovery in first psychotic episode patients in the long term. Working memory impairment was associated with negative psychotic symptoms and functional outcomes, so effective therapeutic interventions could improve outcome of patients.