Abstract
Purpose High frequency oscillations (HFO 80–500 Hz) are recognized as biomarkers for epileptogenic brain tissue to be resected in epilepsy surgery. We analysed here the test-retest reliability of HFO recorded at different times. Method We analyzed long-term invasive night recordings of 11 patients who subsequently had an area of the brain resected and achieved seizure freedom. Four patients had mesial temporal lobe epilepsy (TLE) and seven extratemporal epilepsy (ETLE). For each night, 30-min recordings were extracted during slow wave sleep, artifacts were removed and recordings were segmented into 5-min intervals. HFO were detected by a fully automated algorithm and contacts with the highest rate designated the HFO area for each interval. Results The resected area included the HFO area for all intervals in 3/4 TLE and 5/7 ETLE patients. The scalar product of the normalized rate vectors significantly exceeded a random distribution for every night pair for 4/4 TLE and 3/5 ETLE patients with multiple nights and for all interval pairs for 3/4 TLE and 5/7 ETLE patients. When averaging over all intervals, the resected area included the HFO area for 10/11 patients. Conclusion While the intervals have to be selected carefully from slow wave sleep, the HFO analysis provided high reliability within and between nights for the individual patient.
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