Abstract
Lung cancer ranked as the most common lethal cancer type in the world, with incidence continue rising. KIAA0101, also known as a proliferating cell nuclear antigen (PCNA) binding protein, highly expressed in various types of cancer. However, the prognosis, diagnostic value, and biological function of KIAA0101 have not thoroughly illustrated in non-small lung cancer (NSCLC). We utilized bioinformatics and cell lines to verify the KIAA0101 expression. Functional analyses were conducted to confirm the roles in vitro and vivo. The results identified that KIAA0101 overexpressed in NSCLC tissues and cell lines than normal tissues. High KIAA0101 expression was positively associated with high T stage, nodal invasion, advanced tumor stage, and poor overall survival (OS) (p<0.01). The receiver operating characteristic (ROC) curves showed that KIAA0101 could sufficiently distinguish NSCLC from paired healthy tissues (AUC=0.9691, p<0.0001). The multivariate analysis revealed that KIAA0101 was an independent factor of OS (HR=1.451, 95% CI: 1.073-1.963, p=0.016). Furthermore, KIAA0101 knockdown inhibited the proliferation and migration of NSCLC cells and decreased tumor volume in nude mice.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Tabled 1CharactersiticsUnivariate analysisMultivariate analysisP valueHR95%CIP valueHR95%CIAge (≥60/＜60 years)0.1371.2310.936-1.619Gender (Male/Female)0.0781.2250.977-1.537TNM stage (III-IV/I-II)<0.0012.0811.639-2.642N stage (N1+N2+N3/N0)<0.0011.7081.372-2.1250.0071.4261.102-1.845T stage (T1+T2/T3+T4)<0.0011.9291.480-2.5140.0041.5811.155-2.166M stage (M1/M0)0.0042.1071.268-3.499KIAA0101 expression (High/Low)0.0441.2501.006-1.5530.0491.2491.001-1.559 Open table in a new tab In summary, our findings suggested that KIAA0101 was an influential prognostic and diagnostic factor in NSCLC, and considered to be a potential treating target.
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