P3573Different contribution of sympathetic nerve activity to pulse wave velocity and arterial velocity pulse index in healthy subjects

Abstract

Abstract Background Pulse Wave Velocity (PWV) is associated with the net effect of arterial stiffness and sympathetic nerve activity. Recent study demonstrated the significant relationship between PWV and muscle sympathetic nerve activity (MSNA). Arterial Velocity pulse Index (AVI) is a newly developed parameter, which could evaluate vascular reflected wave, regardless of aortic form. Vascular reflected wave is considered to be associated with sympathetic nerve activity, however little is known about the relationship between AVI and MSNA. Purpose The purpose of this study was to evaluate the relationship between AVI or PWV and MSNA in healthy subject. Method 21 healthy subjects were included in this study. AVI was measured by NAS-1000 (Nihon Koden, Japan), calculated from the time series of occlusive cuff pressure in the left upper arm. Brachial-ankle PWV (baPWV) was measured by BP-203RPEIII (Omron Healthcare, Japan). MSNA was recorded from left peroneal nerve by microneurography using tungsten microelectrode. All measurements were performed in the same day morning. Results The mean age was 31+5 years and body mass index (BMI) 22.5+3.0 kg/m2. In regression analysis, baPWV was significantly associated with age (r=0.64 P<0.05) but not with MSNA or BMI. AVI was significantly associated with MSNA (r=0.73, P<0.05) but not with age and BMI. Conclusion We found that different contribution of MSNA to baPWV and AVI and revealed that AVI was associated with MSNA in healthy subjects. These results suggest that AVI could reflect sympathetic nerve activity compared to baPWV.