P347 Profile of coagulase negative staphylococci native valve infective endocarditis in a referral hospital

Abstract

Abstract Coagulase-negative staphylococci (CNS) are the most frequently isolated microorganisms in early prosthetic endocarditis. On the other hand, they rarely affect the native valve, so the profile of native valve endocarditis by CNS is little known. METHODS Prospective observational study with retrospective analysis of 468 episodes of infectious endocarditis (IE) admitted to our hospital from 2003-2018. Of these, 54 (11%) corresponded to IE by CNS, and 22 were in native valve. We describe the characteristics of these 22 patients and compare them with the group of IE by CNS in prosthesis and devices. RESULTS Average age was 67 years, with 77% male sex. There were no differences in predisposing factors. Acquisition was predominant in-hospital (54%), but only previous manipulation was detected in 31%. The presence of clinical and echocardiographic complications was similar, with higher incidence of heart failure in the native group (81 vs. 34%, p = 0.001). Surgery was indicated in 86%, but only 50% underwent surgery. Mortality was very high (68% ) even greater than the prosthetic/device group, although without significant differences. CONCLUSION IE due to CNS in native valve present clinical complications, frequently require surgery and has a high mortality rate.