P341 Fracture risk in middle-age and older patients with inflammatory bowel disease: A Korean nationwide population-based cohort study

Abstract

Abstract Background Fracture risks and associated factors in middle-age and older Asian populations with inflammatory bowel disease are poorly understood. We investigated fracture risk and the effects of comorbidities and lifestyle habits on the risk of developing fractures in middle-age and older Korean patients with inflammatory bowel disease. Methods We conducted a nationwide population-based cohort study using data from the National Health Insurance Corporation Database. We included patients aged over 40 years with inflammatory bowel disease who received the National Screening Program. We compared patients with age- and sex-matched controls. The incidence of fractures, including vertebral, hip, and other sites was determined using claims data. Results The risk of total fractures and vertebral fractures was significantly higher in the inflammatory bowel disease group [adjusted hazard ratio=1.31, 95% confidence interval=1.16–1.48; adjusted hazard ratio=1.59, 95% confidence interval=1.33–1.92, respectively]. Obesity, diabetes, hypertension, and lack of exercise were associated with an increased risk of fracture in patients with ulcerative colitis. In contrast, risk tended to increase regardless of comorbidities and lifestyle habits in patients with Crohn’s disease. Conclusion The risk of bone fracture, especially vertebral fracture, is high in middle-age and older Korean patients with inflammatory bowel disease. Obesity, diabetes, hypertension, and lack of exercise are risk factors for bone fracture in patients with ulcerative colitis. These findings may be helpful for clinicians to educate patients with inflammatory bowel disease on bone health and raise awareness of bone fractures in patients with ulcerative colitis who have specific risk factors.