P340 The association between colon pseudopolyps presence and clinical adverse events in UC patients treated with biologics

Abstract

Abstract Background Colon pseudopolyps (aka post-inflammatory polyps) are potential marks of previous severe ulcerative colitis (UC) activity. The association between outcomes of patients treated for UC with biologics and presence (or lack of presence) of pseudopolyps, are unclear. Methods A single center, noninterventional retrospective cohort review study was performed on real-life data of adult patients with moderate-to-severe UC who were treated with biologics (infliximab, vedolizumab, ustekinumab) for a minimum of 6 months. The difference in first occurence of treatment failure defined as a negative composite outcome (need for steroid rescue therapy, biologic switch, IBD-related hospitalization and/or surgery) between two groups (with or without pseudopolyps) was investigated. Participants’ characteristics were assessed using descriptive statistics. Normal distribution was assessed using Kolmogorov-Smirnov and Shapiro-Wilk tests. Categorical variables were analyzed using Chi-square test and continuous variables using Mann-Whitney test. Kaplan-Meier analysis and log-rank test were used in order to assess difference in therapy duration between two groups. Results Total of 92 patients (51% females; smokers 17%; 24% with pseudopolyps) were included. There were no differences in key baseline characteristics such as age, sex, smoking status, extraintestinal manifestations, serum albumin and CRP as well as fecal calprotectin levels between groups of patients with or without pseudopolyps. Median duration of follow up was 18.5 months (IQR 8-37). Presence of pseudopolyps was not associated with a higher risk for treatment failure; there was no statisticaly significant difference in the occurrence (χ2(1, N =91)=1.38, p=0.31) of negative composite outcomes or time to develop negative composite factor (χ2(1, N =91)=1.57, p=0.21). Conclusion In our cohort we have failed to detect any association between presence of colon pseudopolyps and rates of first occurence of treatment failure in UC patients treated with biologics.