P340. Altered Mu Opioid Receptor Binding Potential in Adults With a History of Childhood Maltreatment

Abstract

Childhood maltreatment includes neglect and/or abuse within the family during childhood. There is evidence to suggest that adults with past childhood maltreatment have blunted reward and stress processing, possibly due to mu opioid receptor alterations in the nucleus accumbens and amygdala. Accordingly, we hypothesized that nucleus accumbens and amygdala mu opioid receptor density is negatively associated with childhood maltreatment in individuals in a community sample.