P34 Identification of the Genetic Determinants of Susceptibility to Lung Cancer in a Moroccan Cohort

Abstract

Lung cancer is the most common cause of death from cancer worldwide, estimated to be responsible 1.59 million deaths, representing 19.4% of all cancer types. Representing 80–85% of all cases non–small cell lung cancer (NSCLC) is the most predominant type of lung cancer. Lung cancer has been recognized as a complex multifactorial disease resulting from the interactions between various genetic and environmental factors. Identification of genes involved in the occurrence and development of lung cancer could contribute to further understanding of the underlying mechanisms, and even a very important additional appropriate prevention strategies and targeted treatments for reducing lung cancer burden. Many studies have suggested that key cytokines in inflammation pathways may exert important roles in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammatory and immune response genes influence lung cancer risk in Moroccan patients. Using a candidate gene approach, 6 single nucleotide polymorphisms (SNPs) in 4 genes were assessed in 117controls and 117 lung cancer patients. Genotyping was performed with the TaqMan® allelic discrimination technology. The results were analysed using SPSS 24.0 software. Among the 5 studied genes, we found a significant association for the MIF (rs755622) (OR=1.63; 95% confidence interval 1.04-2.56; p =0.03), IL-6 (rs2069840) (OR=1.63; 95% confidence interval 1.08-2.47; p =0.01) and STAT3. No significant association was observed for the remaining SNPs in the following genes: IL17A rs7747909, IL-6R_rs2228145, IL6ST_rs2228044. The results founded suggest the important role of genetically determined high inflammatory response in the pathogenesis of lung cancer in the Moroccan population.