P330. Resting-State Functional Connectivity of Repetitive Negative Thinking in Major Depression

Abstract

Repetitive negative thinking (RNT), i.e. the cognitive process that encompasses past- (rumination) and future- (worry) directed thoughts, is a transdiagnostic construct that is relevant for major depressive disorder (MDD) and anxiety. Severe RNT often occurs in individuals with severe levels of MDD, which makes it challenging to disambiguate the neural circuitry underlying RNT apart from depression severity. In the present study, we used a propensity matching approach including the severity of depression, anxiety, and demographic characteristics to determine the association between RNT and resting-state functional connectivity.