Abstract
In a previous paper we have described the effect of adrenalectomy on the uptake of radioactive phosphorus (P32) in the rat (Lingjærde et al., 1958). The purpose of this investigation is to study the effect of hypophysectomy on the uptake of P32 by the brain, endocrine glands and other organs of adult male rats. The results obtained are different from those reported by other workers, probably because of different standards used for calculating the relative specific activities. Adult male Wistar rats hypophysectomized by the parapharyngeal route were obtained commercially, and used 6–7 weeks after operation. They were kept on the usual diet in our laboratory, and no substitutional therapy was given. No traces of pituitary tissue were found in any of the animals at autopsy. Administered intraperitoneally with a Krogh-Keys graduated 1 ml. syringe, exactly 250 microcuries of P32 are given to the animals 2.5 hours
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