P311 Use of cyclosporine as a steroid-sparing agent in a patient with hypereosinophilic syndrome

Abstract

Hypereosinophilic syndromes (HES) are a group of disorders characterized by persistent blood eosinophilia =1500x10e6/L in the absence of a secondary cause and eosinophil-associated organ dysfunction. Glucocorticoids are usually the initial therapy, and steroid-sparing agents are added later (e.g. hydroxyurea, methotrexate, interferon-alfa, mepolizumab). Cyclosporine is an immunosuppressant whose use has been documented in a few case reports. This case describes its use in a patient with symptoms uncontrolled on low-dose steroids despite suppression of absolute eosinophil count (AEC).