Abstract
Sleep deprivation results in a robust antidepressant response in 50% of individuals with major depression (MDD), with anhedonia being a strong predictor of response. Although the mechanism of this antidepressant effect is not known, one potential candidate may be via the modulation of neuroplasticity. Sleep slow-wave activity (SWA) has been suggested to facilitate the homeostatic modulation of neuroplasticity; thus, in this study we aimed to examine if selectively reducing SWA via auditory stimulation could improve mood and motivation in individuals with MDD with anhedonia.
Published Version
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