Abstract
Introduction The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation, activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in Streptozotocin (STZ) induced diabetic cardiomyopathy (DCM) [1]. Method Diabetic cardiomyopathy was induced by single intraperitoneal injection of STZ (40 mg/kg) combined with high energy intake in Wistar strain rats. Seed extract of Cichorium intybus (CIE) (250 mg and 500 mg/kg) was administered orally once a day for 3 weeks. Result Administration of CIE reduced the lipid peroxides level in heart. Serum levels of AST, GSH, LDH and SOD (5.44 vs 7.84 were brought down to physiological levels by CIE in STZ induced DCM rats. CIE also markedly down-regulated serum TNF-α (122.5 ± 3.81 vs 206.33 ± 5.04) and IL-6 (36.16 ± 1.1 vs 27.83 ± 0.70) levels. Catalase (13.13±0.59 vs 29.84±0.81) that was reduced in serum was brought back to near normal level. The extensive necrotic changes of cardiac tissue by STZ were minimized to normal morphology upon CIE administration. Conclusion The study demonstrates the cardio protective effect of CIE via inhibition of oxidative stress and pro-inflammatory cytokines.
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