Abstract
Disturbances of thyroid function are often accompanied by cognitive and affective disorders. Assessment of cognitive status in the patients with subclinical hypothyroidism represents a possibility for early diagnostics of cognitive impairment and timely introduction of necessary pharmacotherapy treatment. The aim of this study was to quantify whether there are P3 event related potential (ERP) deviations as electrophysiological markers of cognitive activity in patients with subclinical hypothyroidism. P300 potentials were examined in thirty patients with subclinical hypothyroidism and in 30 healthy subjects of the control group. P300 was recorded using the classic auditory oddball paradigm, with 20% of target and 80% of non-target stimuli. The results analysis showed a significantly longer latency P300 and reduced amplitude P300 in subjects with subclinical hypothyroidism compared to euthyroid subjects. There is also a statistically significant negative correlation between the results of a mini mental state examination and the P300 latency at Fz electrode (r= -0.47, p <0.01) and Cz electrode (r= -0.43, p =0.017). P300 ERP is important in the evaluation of patients with subclinical hypothyroidism, due to the sensitivity in the detection cognitive disorders.
Highlights
It is known that thyroid hormones are important for normal brain function [1,2]
Manifest hypothyroidism can lead to changes in many cognitive domains, including attention, concentration, memory, executive function, and impact of subclinical hypothyroidism on cognitive function is still unclear [3]
There is no consensus in the literature whether the subclinical hypothyroidism may induce change of the cognitive functions
Summary
It is known that thyroid hormones are important for normal brain function [1,2]. Disturbances of thyroid function are often accompanied by cognitive and affective disorders. Subclinical hypothyroidism may have similar, but more subtle effects on cognitive functions. Subclinical hypothyroidism, defined as an asymptomatic state with elevated serum thyroid stimulating hormone (TSH) levels while the values of free and total tyroxin (T4) are normal [4]. There is no consensus in the literature whether the subclinical hypothyroidism may induce change of the cognitive functions. Some authors argue that the mild subclinical hypothyroidism (average TSH concentration less than 10mU/L) may induce cognitive and affective disorders which can be corrected by the tyroxin substitution [5]. There are increasingly more evidence of a disturbance of cognitive function under subclinical hypothyroidism. Many authors believe that the decline in cognitive function may vary depending on the concentration of thyroxine
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