Abstract
BackgroundThe P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function). This paper reviews the development of the auditory P300 across the lifespan.Methodology/Principal FindingsA systematic review and meta-analysis on the P300 was performed including 75 studies (n = 2,811). Scopus was searched for studies using healthy subjects and that reported means of P300 latency and amplitude measured at Pz and mean age. These findings were validated in an independent, existing cross-sectional dataset including 1,572 participants from ages 6–87. Curve-fitting procedures were applied to obtain a model of P300 development across the lifespan. In both studies logarithmic Gaussian models fitted the latency and amplitude data best. The P300 latency and amplitude follow a maturational path from childhood to adolescence, resulting in a period that marks a plateau, after which degenerative effects begin. We were able to determine ages that mark a maximum (in P300 amplitude) or trough (in P300 latency) segregating maturational from degenerative stages. We found these points of deflection occurred at different ages.Conclusions/SignificanceIt is hypothesized that latency and amplitude index different aspects of brain maturation. The P300 latency possibly indexes neural speed or brain efficiency. The P300 amplitude might index neural power or cognitive resources, which increase with maturation.
Highlights
Almost half a century ago, the group of Samuel Sutton and E.R
The present paper will review and analyze the developmental process of the auditory P300 across the lifespan employing 1) a systematic review and meta-analysis of all studies published over the last half century and 2) an independent crosssectional dataset including 1,572 participants
Characteristics of the P300 The ERP is quantified by averaging activity in the electroencephalogram (EEG) time-locked to a specific event, for instance an auditory stimulus
Summary
Almost half a century ago, the group of Samuel Sutton and E.R. John first described the P300 [1], a component from the eventrelated potential (ERP), which has been intensively investigated since . The present paper will review and analyze the developmental process of the auditory P300 across the lifespan employing 1) a systematic review and meta-analysis of all studies published over the last half century and 2) an independent crosssectional dataset including 1,572 participants. Characteristics of the P300 The ERP is quantified by averaging activity in the electroencephalogram (EEG) time-locked to a specific event, for instance an auditory stimulus. This results in a waveform associated with the processing of that specific event. The P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function). This paper reviews the development of the auditory P300 across the lifespan
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
