Abstract
To examine the left temporal scalp area reductions of P300 amplitude, event-related potentials (ERPs) during a standard oddball task were recorded in 57 schizophrenic patients and 33 normal controls. The P300 amplitude at T3 was not significantly smaller than that at T4 in schizophrenic patients. In the ANOVA analysis of P300 peak amplitude, significant lateral topographical differences in P300 were not present between patients and controls. However, in schizophrenia, patients in the low T3 P300 group have relatively low P300 amplitudes and significantly delayed P300 latency, compared with those in the high T3 P300 group. These findings suggested that the reduction of left temporal P300 amplitude may be associated with the severity of the disease process and/or impairment of cognitive function.
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