Abstract
Objectives: The objective was to estimate a reference range of 3D embryo volume using VOCAL for pregnancies between 7 & 11weeks. Methods: This is a cross-sectional study including 60 singleton pregnancies with an E6 (GE, USA)with an endocavitary volumetric 4–9 MHz probe, using VOCAL with a manual tracer at 30◦, the outer aspect of the embryo was drawn manually on every image displayed sequentially in this plane. At the end of the 180◦ rotation, the built in software calculated the volume automatically. Results: The mean CRL was 23.7 ± 9.0 mm (range 9 to 38 mm). Mean fetal volume was 1.7 ± 1.2 cm3 (range 0.35 to 4.0 cm3). There was a strong positive correlation between fetal volume and menstrual age, gestational age and CRL (r = 0.919, 0.938 and 0.941, resp.). Power regression model produced an R2 value of 0.880 with a regression equation (y = 8.657 * ×0.150). The predicted gestational age fitted well with that predicted from CRL with a minimal difference and a P of 0.234. Conclusions: This pilot study demonstrated a strong correlation between fetal volume estimation and crown-rump length measurement for the prediction of gestational age (r = 0.950). Embryonic/fetal volume is a good predictor of gestational age with a power regression equation (y = 8.657 * ×0.150) for the period from 7 weeks to 10 weeks + 6 days.
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