P3: CASE-CONTROL STUDY OF SEXUAL BEHAVIOUR IN HPV-POSITIVE ORAL CAVITY AND OROPHARYNGEAL CANCER

Abstract

Abstract Introduction HPV infection is recognised as the main aetiological factor responsible for the increased incidence of oropharyngeal squamous cell carcinomas (OPSCC). Currently the epidemiology of oral HPV infection and OPSCC is poorly understood. In this study we aim to define the relationship between sexual behaviours and HPV-positive OPSCC. Method We performed a hospital-based, case-control study of 30 patients with HPV-positive and 30 patients with HPV-negative newly diagnosed oral cavity and OPSCC. The participants underwent questionnaire based interviews investigating variables such as age, gender, tobacco use, alcohol intake, and sexual behaviour. Result Subjects in the HPV-positive tumour subgroup had significantly less tobacco use then their HPV-negative counterparts (odds ratio, 0.92, 95% CI 0.9-1.17). A history of oral sexual activity was significantly more likely in the HPV-positive tumour subgroup (odds ratio, 5.23, 95% CI, 1.66-16.51), however this association did not remain significant when adjusted for age, gender, smoking and alcohol consumption. Similarly, there was significantly less alcohol consumption overall in the HPV-positive tumour subgroup (odds ratio, 0.107, 95% CI 0.96-1.01), but this association was no longer significant when adjusted for covariables. Conclusion Significantly less smoking was prevalent in patients with HPV-positive OPSCC. Although patients with HPV-positive tumours had less alcohol consumption and a stronger history of oral sexual activity overall, greater numbers are required in order to show a significant association. This further supports the known association between HPV-infection and OPSCC and the department of health's decision to commence vaccination of boys before the onset of sexual activity. Take-home message HPV-positive oropharyngeal cancer can develop without exposure to established risk factors such as tobacco use or excessive alcohol consumption. This change in pathogenesis should lead a change in how we prevent and manage the disease.