Abstract
Cell bodies of afferent neurons which innervate urinary bladder are mainly located in the lumbosacral dorsal root ganglia (DRG). They provide Aδ- and C-fibres which report information about bladder wall tension, volume and noxious stimuli. Recently, muscarinic acetylcholine receptor (mAChRs) activation in bladder sensory pathways was reported to alter reflex bladder activity. In addition, activation of nicotinic acetylcholine receptors (nAChRs) in C-fiber bladder afferents can induce detrusor overactivity (DO).
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