P3-257: Comparison of 5-year survival rate in surgically treated IB and IIA NSCLC patients

Abstract

The group of patients operated on for N1 NSCLC is considered very heterogeneous in terms of 5-year survival rates. Therefore we have decided to compare 5-year survival rates operated on at our institution for NSCLC in pathological stage of T2N0 and T1N1. We reviewed retrospectively the data of 696 patients who underwent the lung resection for NSCLC in our institution between January 1998 and December 2000. In all of them the complete lymphadenectomy (hilar and mediastinal) was performed along with lung resec-tion. The stage of the disease was estimated as IB in 181 pts (26,6%) and as IIA in 44 pts (6,3%). (N1 was confirmed in 221pts out of 696 oper-ated on). 5-year survival rate in IB and IIA groups was 61% and 54,5% respectively. We accepted the p value < 0,001 in log rank test as the statistically significant. We have found no statistically significant influence of age (59,4% in <50 year old pts and 59,4% in >70y old pts, p<0.55), type of resection (63,8% in lobectomy, 56,3% in pneumonectomy, p<0.69), histology (59,7% in adenocarcinoma, 61,3% in squamous cell, p=0,93), T value (p=0.66), presence of neoplastic tromboli in lymphatic vessels (50% of positive, 61,1% if negative, p< 0,34) or infiltration of nerves (61% if negative, 47,1% if positive, p<0,28) on 5-year survival rate. Among patient with N1 there was no statistically significant difference between hilar and intrapulmonary lymphatic spread - the 5-year sur-vival rate was 60,9% and 52,7% respectively (p<0,32). Each of these two groups of hilar lymphnodes were divided into two subgroups. There was also no statistically significant difference within both of them. In hilar lymphnodes - groups 10 and 11 - the 5-year survival rate was 60.9% and 52.7% (p < 0.32) respectively and in intrapulmonary lymphnodes - groups 12 and 13 - 5-year survival rate was 51.5% and 48.3% (p<0.56) respectively. Marginal statistically significant influence on 5-year survival rate we found comparing the sex of patients (M -55,1%, F - 61,1,%, p < 0,01) and presence of neoplastic emboli in blood vessels (52,6% if positive and 64,4% if negative, p < 0.08). The lack of statistically significant differences between these two groups of patients let us suggest combining them into one group.