P3.13-001 Clinical Significance of Chest Tomography Characteristics in Non-Small Cell Lung Cancer Patients Who Received Anatomic Resection

Abstract

Characteristics of CT image, including tumor size and component were correlated to survival. However, most studies discuss the survival impact of image characteristics in early clinical stage populations. No articles were discussed the issue from the view of pathology stage, i.e. actual disease presentations of non-small cell lung cancer patients who presented as resectable disease. The aim of study was to analyze radiologic and pathologic findings of non-small lung cancer patients who received curative resection in order to clarify he clinical correlation between image characteristics and survival impaction. From 2010 January to 2014 May, 440 patients who underwent curative resection, i.e. anatomic resection and mediastinal lymph node resection, were included and medical record were reviewed retrospectively. Chest CT characteristics, including tumor size and consolidation-tumor ratio, were re-evaluated and re-measured by radiologists. The correlation between image and pathology characteristics and its survival impaction were analyzed. We identified tumor size presented in CT and pathologic measurements were highly coincidence (p-value<0.001). The presentation of pure GGO and GGO predominant lesion were adenocarcinoma (p<0.001). Majority of these lesions (61/76, 80.2%) were well differentiated (p<0.0001). In addition, pure GGO lesion has less risk for visceral pleura (p <0.0001), angiolymphatic invasion (p <0.002), and lower risk with N1 lymph node metastasis (p = 0.004) In addition, we found excellent disease free and disease free survival for patients who was identified GGO predominant lesion with size ≤2cm. (Fig 3) The difference of disease free (p= 0.0032, log rank test; Fig 3A) and overall survival (p= 0.0066, log rank test; Fig 3B) of these four subgroups was statistically significance. Non-small cell lung cancer patients who presented with ground glass opacity were corrected with well differentiated adenocarcinoma. In addition, less visceral pleura invasion, less angiolymphatic invasion, and less intrapulmonary lymph node metastases risk were also identified. Our results showed lung cancer patients who presented as GGO predominant lesions and size less than 2 cm may had excellent disease free and overall survival.