Abstract
Hypertrophic Obstructive Cardiomyopathy (HOCM) is characterised by asymmetric septal hypertrophy and is associated with lethal ventricular arrhythmias. Gap junction remodeling and associated alterations of tissue impedance may lead to conduction slowing which may predispose to arrhythmias. We measured tissue impedance in 7 left ventricular septal myectomy preparations from patients diagnosed with HOCM (5M, 45 ± 10.6 years, all NYHA III) and quantitatively determined levels of the major ventricular gap junction protein connexin 43 (Cx43) in each patient.
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