P3-09-01: Change in Carbohydrate Intake and Breast Cancer Prognosis.

Abstract

Abstract Breast tumors over express insulin-like-growth-factor receptors (IGF-IR), and levels of expression may be inversely related to tumor grade. Dietary factors, particularly carbohydrate intake, may stimulate activation of IGF-1R and affect prognosis. METHODS: Data are from N=2,651 women in the Women's Healthy Eating and Living (WHEL) Dietary Intervention trial, a plant based intervention trial that did not have a carbohydrate goal. All women were diagnosed with breast cancer within the previous 4 years. Carbohydrate dietary intake data were extracted from multiple 24-hour dietary recalls at study entry and one year, and were compared by recurrence status. Time to recurrence was modeled on year-one change in carbohydrate intake adjusted for baseline intake, menopausal status, and disease, treatment, and study characteristics. RESULTS: Baseline carbohydrate intake was 233 g/day. Women who recurred had a mean increase in carbohydrate intake over the first year, compared to those who did not recur (2.3 vs. −2.7 g/day; p=0.188). Change in starch intakes accounted for 48% of the change in carbohydrate intake (R-squared: 48%; p<0.001). Baseline starch intake did not differ by recurrence status (95.8 g/day; p=0.219). Mean year-one change in starch intake was −4.1 g/day among women who recurred vs. −8.7 g/day among women who did not recur (p=0.015). Year-one change in starch intake was independent of the study intervention (p=0.326). In the adjusted model, a 5-g/day increase in starch related to a 3% increased risk of recurrence (HR=1.03; 95% CI 1.01 - 1.06; p=0.017). The increased risk was limited to women diagnosed with low grade tumors (Table 1). DISCUSSION: Dietary modifications targeting starch intake warrant further investigation as a preventive measure against breast cancer recurrence. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-09-01.