P3.07-017 Joinpoint Regression Analysis of Lung Cancer Mortality, Turkey: Topic: Other – Geographical Differences

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It is important to investigate the variation of the deaths due to lung cancer in time. The aim of this study is to investigate the variations in the rate of deaths due to lung cancer in Turkey. Data on lung cancer mortality during 2009-2014 years were extracted from the Turkish Statistical Instıtute and Turkey Public Health Agency mortality data based on Internal Classification of Diseases 10(ICD-10)codes C32-C34. For each gender, age group-specific and standardized rates were calculated by direct standardized method (using the world standard population). These were expressed as rates/100,000 persons. The temporal trend in lung cancer mortality rates were tested for age, gender and methods using Join point Regression Analysis. In join point regression analysis, the best-fitting points where the rate changes significantly (increase or decrease) are chosen. Each join point indicates a statistically significant change in trend, and annual percentage change (APC) is computed for each of trend by means of generalized liner models assuming a Possion distribution. 119.778 deaths due to lung cancer were recorded; 85.50% (n=102409) of the were in men,14.50% (n=17369)were in women. The mean of crude rate of lung cancer mortality is from 2009 (23.77 deaths/100.000) to 2014 (26.78 deaths/100.000) 26.19 in 100.000, in men 44.00 in women 7.74. The mean of lung cancer age-specific standardized rates from 2009 (49.47 deaths/100.000) to 2014 (54.57 deaths/100.000) is 52.50 in 100.000, in men 45.83 and in women 6.62. Lung cancer mortality rates shows a significant increase between 2009-2014. The rates of lung cancer mortality, between 2009 and 2014 with 4.2% (%95 Confidence Interval: 3.2 to 5.3) showed an important increase annually (p<0.001). During working period, throughout men the variation 4.1% (2.8 to 5.5) in the lung cancer mortality rates were significant (p<0.001). Similar situation was in women with 5.0% (3.7 to 6.4) (p<0.001). The deaths due to lung cancer in young age (under 44 years) in women (5.27%) is more than men (2.59%)(p<0.001). The decrease of -5.4% (-1.5 to 5.3) in deaths due to lung cancer seen in young men (under 45 years) within years was not significant (p=0.20). Similarly in women with same age the variation 3.1% (-2.7 to 9.3 was not significant (p=0.30). The variation in men between the ages45-64 deaths due to lung cancer within years 1.5% (-0.3 to 3.4) was not significant (p=0.10). Unlike in women in this age group with 3.8% increase (2.2-5.5) showed significance (p<0.001). The increase in deaths due to lung cancer seen in men in 65 years of age and over 4.4% (3.6-5.2)was significant (p<0.001). With the same result in women 2.6%increase (1.1-4.1) was seen (p<0.001). Even though deaths due to lung cancer show non-significant decrease in male, shows significantly increase above 65 years of age. Increase in lung cancer in young women is remarkable.