Abstract
correlated with AAO in the PCA patients. Results:Early onset PCA was associated with lower cortical thickness bilaterally in the inferior parietal lobe, angular gyrus and precuneus, whilst late onset PCAwas associated with lower thickness in frontal and medial temporal lobe regions (Figure 1). Consistent with the imaging findings, early onset PCA was associated with worse performance on digit span (0.53, p 1⁄4 0.001), calculation (0.48, p 1⁄4 0.003) and spelling (0.29, p1⁄4 0.026) all of them tests associated with dominant parietal function. Conclusions: Our data suggest that early-onset PCA patients have a greater involvement of bilateral (especially dominant) posterior cortices, and question the factors driving the relationship between age at onset and phenotypic heterogeneity not just between but also within the recognised atypical AD phenotypes.
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