Abstract
Results: Univariate analysis demonstrated that factors associated with mortality at the end of treatmente were: age; Apache II >15; presence of bacteremia; treatment with polymyxin; mechanical ventilation; and hemodinamic instability. Multivariate analysis showed that treatment with polymyxin (OR: 2.27; 95% IC 1.16–4.54); bacteremia (OR: 2.41; 95% IC 1.18– 4.97); Apache II >15 (OR: 2.0; 95% IC 1.08–3.7) and older age (OR: 1.55; 95% IC 1.11–2.15) were independently associated with death during treatment. However, the multivariate analysis to assess mortality during hospitalization revealed that treatment regimen was not associated with worse prognosis. Overall mortality was high: 63% for A/S and 75% for polymyxin (p = 0.11). Conclusions: Patients treated with polymyxin presented an independently higher risk of dying during treatment than with A/S, but not during hospitalization. Infection by Acinetobacter spp resistant to imipenem seems to be a marker of poor prognosis as death occurred in 69% of patients.
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