P3.01-054 Urinary ct-DNA Testing of EGFR Common Mutation in Non-Small Cell Lung Cancer Patients

Abstract

The existence of circulating tumor DNA (ct-DNA) in urine as a noninvasive and alternative sample to tissue biopsy has been promising. However, it still has some challenges. Common mutations of epidermal growth factor receptor (EGFR), such as L858R in exon 21 mutation has been used to predict lung cancer treatment response to tyrosine kinase inhibitors (TKI). The study aimed to demonstrate that DNA from urine can be detected using simple methods with high sensitivity, enabling early Non-Small Cell Lung Cancer (NSCLC) detection from these noninvasive samples.