Abstract
Abstract Microglia, the resident macrophages of the brain, have recently been revealed to be essential in regulating brain functions. However, there are limited methods that allow fluorescence labeling of microglia for their functional analysis. Herein, we demonstrate that a ligand for P2Y12 receptors, which is specifically expressed in microglia in the brain, can be leveraged for rational design of microglia imaging probes. Our design strategy is flexible as it can tune the fluorescence wavelength, affording new fluorescent probes of microglia.
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