P.2.b.056 Time course of psychomotor performances, fatigue and cognitive function in stable in-patients with treatment resistant depression

Abstract

as well as the average night sleep duration (ANSD) during this time period. Suicidal intent was recorded with the 15-item Beck’s Suicide Intent Scale (BSIS). BSIS score was sequentially regressed on AIS total score, specific AIS items, self-reported insomnia and ANSD after adjusting for gender, age and current depression or MDI score. Results: 102 subjects (63.7% females), aged 16−87 (43.8± 18.1) years were included. Assessments took place 4.2±4.4 days after the suicide attempt. 55.9% reported previous attempts. 50% had regular psychiatric consultations for mental health problems and had been previously diagnosed with affective disorder (26.5%), schizophrenia (7.8%), personality disorders (2.9%) or alcohol abuse (2%). 48% received psychotropic medication during the month preceding the attempt. Methods employed in the most recent suicide attempt included drug-overdose (80.4%), selfpoisoning (6.9%) and self-injury (12.7%). 38.2% of participants fulfilled DSM-IV-TR criteria of current major depressive episode. During the two-week time period before the attempt, 55.9% reported suffering from insomnia while 41.2% slept less than 5 hours per night on average. 35.3% of attempters scored high on BSIS (>=14) while 44.1% had intermediate scores (5−13). After adjusting for covariates in multiple regressions, BSIS was independently associated with AIS total score (p = 0.007), ANSD (p = 0.037) and ANSD 5hr (p = 0.025). Interactions of gender, age and current depression with sleep measures (AIS score, ANSD) tested non-significant. Out of specific AIS items, items 2 (night-time awakenings) (p = 0.007), 3 (late insomnia) (p = 0.001) and 4 (inadequate sleep duration) (p = 0.004) were significantly associated with BSIS, while item 8 (somnolence) was associated at a trend level (p = 0.08). Conclusions: In conclusion, suicide intent was found to be associated with the severity of insomnia and short self-reported sleep duration (less than 5 hours per night on average) during a two-week time period preceding the suicide attempt independently of the presence of a current major depressive episode. In specific, night-time awakenings (middle insomnia) and early arousal (late insomnia) were strongly associated with suicide intent.