P297 Takayasu arteritis presents at an older age in a northern European population

Abstract

Abstract Background/Aims The definition of Takayasu arteritis includes the age of onset of disease as being <50 years. It has been reported most frequently in young females from Asian populations. We investigated whether the epidemiological features are the same in Norfolk, where the population is predominantly of northern European ancestry. Methods n our centre, cases are classified using validated international criteria. The electronic records of our vasculitis clinic were reviewed to identify all individuals with a new diagnosis of large vessel vasculitis from 2011-2020 who met a modified ACR 1990 criteria for Takayasu arteritis. The original criteria include decreased brachial artery pulse, bruit over subclavian arteries or aorta, and arteriogram abnormality. The respective modifications of these three criteria were to accept decreased radial pulse as well as the brachial pulse, bruit over the axillary artery as well as the subclavian artery, and abnormality of positron emission tomography and/or ultrasonography instead of arteriograms. Results 14 individuals met the modified ACR 1990 criteria for Takayasu arteritis. 13 were female. The mean (standard deviation) age at diagnosis was 68.2 (7.7) years. None of the individuals were <40 years old. On presentation, 8 had upper limb claudication, 8 had pulse discrepancy, 4 had a blood pressure difference >10 mm Hg systolic, and 8 had an audible bruit over either subclavian or axillary artery. The diagnosis was confirmed on positron emission tomography in 7, ultrasonography of extracranial arteries in 5, and 2 by both modalities. The mean (standard deviation) ESR was 66.7 (48.1) and CRP was 49.2 (33.8). 2/14 also met the ACR 1990 criteria for GCA. Conclusion Takayasu arteritis can present at an older age in Norfolk where the population predominantly has northern European ancestry. Some of these individuals also fulfil the criteria for GCA. This has implications for treatment, identification of immunogenetic factors and disease classification. Disclosure T. Ecclestone: None. F. Coath: None. G. Ducker: None. S. Fordham: None. C. Mukhtyar: None.