P281 Children with cystic fibrosis demonstrate high rates of asymptomatic carriage of Clostridioides difficile

Abstract

Cystic fibrosis (CF) is a multisystem, genetic disease which causes significant alteration to the intestinal microbiome. Intestinal dysbiosis and inflammation in CF are well-documented but their pathophysiology is poorly understood. In addition, adults with CF exhibit higher prevalence of Clostridioides difficile infection (CDI) and asymptomatic carriage rates of up to 50% with non-significant clinical effects. However, the prevalence and significance of Clostridioides difficile carriage among children with CF is unknown. Intestinal dysbiosis and inflammation may potentially foster an environment for Clostridioides difficile carriage in CF patients, thus warranting investigation.