Abstract
The realization that surface-active block copolymers (Poloxamers) can be used to restore the structural integrity of permeabilized cell membranes [1] has established new methods for repairing damaged cell membranes [1-4]. The main goal of the present work is to understand the nature of the interactions between copolymer surfactants and membranes that lead to the restoration of structurally compromised membranes. We characterize structural changes in fibroblast cell membranes associated with the observed permeability increases due to a chemical injury by saponin and successive Poloxamer 188 (P188) mediated membrane sealing by using atomic force microscopy (AFM).
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