P261. Using Computational Approaches for Predictive Models of Antidepressant Response: Integrating Biological Networks With Clinical Outcomes

Abstract

There is a need for new mechanistic models to develop objective tools that can aid the diagnosis of depression and monitor antidepressant responses. We and others showed that, in rodent models, administration of acetylcarnitine (LAC) leads to rapid and sustained antidepressant response by epigenetic regulation of glutamatergic function in key brain areas, such as the ventral dentate gyrus. Using exosomes, our group also showed decreased levels of the pivotal mitochondrial metabolite LAC in clinical endophenotypes of depression characterized by brain insulin resistance.