P26.07: Androgen levels in female offspring of PCOS and non‐PCOS women

Abstract

The etiology of polycystic ovary syndrome (PCOS) is not particularly mapped, but a complex interaction of various factors can be assumed. Experimental studies in non-humans and clinical observations in humans raise the hypothesis that developmental programming by androgen excess in utero plays a role in the development of PCOS. Our study aimed to evaluate whether the female offspring of PCOS women already show higher androgen levels compared to the female offspring of non-PCOS women. Androgen levels were determined in maternal serum and umbilical cord blood from PCOS and non-PCOS women and the respective offspring at the Medical University of Graz, Austria, between 2012 and 2015. A total of 79 PCOS and 354 non-PCOS women were recruited. The main results are shown in table 1. The comparison revealed that androgen levels in female offspring of PCOS and non-PCOS women do not differ although maternal hormone levels differ significantly. P26.07: Table 1.