P256. ABCB1 Gene Variants and Antidepressant Response and Tolerability: A Systematic Review and Meta-Analysis Including Results From the CAN-BIND-1 Cohort

Leen Magarbeh,Maximilian Choi,Claudia Hassel,Clement C Zai,Natalie Freeman,Victoria Marshe,Farhana Islam,Roseann S Gammal,Stefan Kloiber,James Kennedy,Sidney H Kennedy,Chad A Bousman,Daniel J Mueller,The Canbind Investigator Team

doi:10.1016/j.biopsych.2022.02.492

P256. ABCB1 Gene Variants and Antidepressant Response and Tolerability: A Systematic Review and Meta-Analysis Including Results From the CAN-BIND-1 Cohort

Leen Magarbeh, Maximilian Choi + Show 12 more

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https://doi.org/10.1016/j.biopsych.2022.02.492

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Journal: Biological Psychiatry

Publication Date: Apr 28, 2022

Affiliation: MCPHS University, University Health Network, Queen's University, Centre for Addiction and Mental Health, University of Toronto, University of Calgary

#ABCB1 Gene Variants #Antidepressant Treatment Outcomes + Show 8 more

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Abstract

The p-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we investigated the association between selected ABCB1 single nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes, including new and unpublished data from the Canadian Biomarker and Integration Network for Depression (CAN-BIND-1) cohort.

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