P2544Acute effects of synthetic cannabinoids on ventricular repolarization parameters

Abstract

Abstract Bacground The association between ventricular repolarization parameters (VRP) and ventricular arrhythmias has been shown in previous studies. However, there are limited data on the association between synthetic cannabinoids (SCs) and VRP. Purpose To analysis the acute effects of SCs on VRP by using T-peak to T-end (Tp-e) interval, Tp-e/QT ratio and Tp-e/QTc ratio. Methods The present study included 58 patients who admitted to the emergency department and who used of SC (SC+) during the years 2014–2016, and 50 healthy control subjects (SC−). QT and QTc intervals, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were measured from the 12-lead electrocardiogram in all subjects. Then, this parameters were compared between the groups and were performed correlation analysis. Results The Tp-e and QTc intervals were significantly higher in SC+ when compared to SC- (92.2±10.0, 77.4±9.3, p<0.001; 434.5±30.8, 410.9±27.3, p<0.001, respectively). Tp-e/QT and Tp-e/QTc ratios were increased in SC+ in comparison to SC− (0.26±0.02, 0.22±0.02, p<0.001; 0.21±0.02, 0.18±0.02, p<0.001, respectively). Significant correlations were found between use of SC and Tp-e interval (r=0.610, p<0.001), Tp-e/QT (r=0.655, p<0.001) and Tp-e/QTc ratios (r=0.437, p<0.001). Table 1. Electrocardiographic findings in between SC+ group and SC− group. SC+ group (n=58) SC− group (n=55) p value QRS duration (ms) 92.6±8.2 90.1±7.9 0.492 QT (ms) 348.4±29.0 353.4±30.7 0.301 QTc (ms) 434.5±30.8 410.9±27.3 <0.001 Tp-e (ms) 92.2±10.0 77.4±9.3 <0.001 TPe/QT ratio (ms) 0.26±0.02 0.22±0.02 <0.001 TPe/QTc ratio (ms) 0.21±0.02 0.18±0.02 <0.001 Conclusion The present study revealed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios increased in subjects who used SC. Therefore, SC users might have an increased risk of ventricular arrhythmia.