Abstract
Malignant pleural mesothelioma (MPM) is rare and fatal malignancy related with exposure to asbestos. Nutritional status has been associated with outcomes in cancer patients. This study aimed to investigate whether the nutritional risk for malnutrition detected by a new nutritional screening tool specifically for oncology patients (NUTRISCORE) an indicator of nutritional status, affects outcomes in patients with malignant pleural mesothelioma (MPM). Patients with biopsy confirmed pathological diagnosis of advanced malignant pleural mesothelioma were eligible in this study. Demographic and clinical data were collected. Nutritional risk status was estimated by NUTRISCORE at diagnosis in routine screening evaluation before systemic treatment. A score ≥5 was taken as nutritional risk. Kaplan-Meier survival analysis and the log-rank test were used to calculate OS. Univariate and multivariate analysis to identify variables associated with OS were assessed using Cox regression model.The data capture and statistical analysis will be carried out in the SPSS v.20 program (SPSS Inc, Chicago, IL, USA). We evaluated a total of 31 patients. The median age for the patients was 53.1 ± 13.4 years old. Patients comprised 26 males (83.8 %) and 5 females (16.1 %); male/female ratio: 1/0.26). By WHO classification criteria for pleural tumor, 80.6 % (25/31) of the tumors were epithelioid cell type and 19.4 % (6/31) nonepithelioid cell type. Among these patients, 29% were classified as stage III and 71% stage IV. According to NUTRISCORE, 18 (22.6%) were at risk for malnutrition (score≥5) and 13 (41.9%) no nutritional risk. Median OS of patients in the malnutrition risk and no risk was 9.36 and 27.3 months, respectively. The Kaplan–Meier method and log-rank test indicated that malnutrition risk was associated with shorter OS (P = 0.028). In multivariate analysis, nutritional risk and involuntary weight loss were independent prognostic factors for OS. In conclusion our study showed that NUTRISCORE risk, an indicator of nutritional status that is simple to assess, is a useful predictor of the long-term outcome of MPM and a factor to attend in these patients.
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